Targeting Xist with compounds that disrupt RNA structure and X inactivation
Targeting Xist with compounds that disrupt RNA structure and X inactivation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Although more than 98% of the human genome is non-coding
1
, nearly all of the drugs on the market target one of about 700 disease-related proteins. The historical reluctance to invest in non-coding RNA stems partly from requirements for drug targets to adopt a single stable conformation
2
. Most RNAs can adopt several conformations of...
Alternative Titles
Full title
Targeting Xist with compounds that disrupt RNA structure and X inactivation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11549687
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11549687
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04537-z
