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Targeting Xist with compounds that disrupt RNA structure and X inactivation

Targeting Xist with compounds that disrupt RNA structure and X inactivation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11549687

Targeting Xist with compounds that disrupt RNA structure and X inactivation

About this item

Full title

Targeting Xist with compounds that disrupt RNA structure and X inactivation

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2022-04, Vol.604 (7904), p.160-166

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Although more than 98% of the human genome is non-coding
1
, nearly all of the drugs on the market target one of about 700 disease-related proteins. The historical reluctance to invest in non-coding RNA stems partly from requirements for drug targets to adopt a single stable conformation
2
. Most RNAs can adopt several conformations of...

Alternative Titles

Full title

Targeting Xist with compounds that disrupt RNA structure and X inactivation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11549687

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11549687

Other Identifiers

ISSN

0028-0836,1476-4687

E-ISSN

1476-4687

DOI

10.1038/s41586-022-04537-z

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