Aβ‐ and Tau‐Mediated Neuronal Excitability Derived from fMRI Predicts Grey Matter Atrophy in Alzheim...
Aβ‐ and Tau‐Mediated Neuronal Excitability Derived from fMRI Predicts Grey Matter Atrophy in Alzheimer’s Disease
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Hoboken: John Wiley and Sons Inc
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English
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Hoboken: John Wiley and Sons Inc
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Background
Despite amyloid‐β (Aβ) plaques and tau neurofibrillary tangles being recognized as major Alzheimer’s Disease (AD) hallmarks, their synergistic contribution to neuronal activity remains unclear. We developed a neuroimaging‐based personalized brain activity model to assess the in‐vivo functional impact of AD pathophysiology. In previous reports, model‐inferred neuronal excitability predicted disease progression (i.e., cognitive performance and certain biological markers) [1,2]. Here, we investigate its relationship with brain tissue atrophy.
Method
We used Aβ and tau PET scans, structural T1‐weighted 3D MRI and resting‐state functional MRI from 132 subjects in the TRIAD cohort (https://triad.tnl‐mcgill.com/, Fig. 1a). The participants were diagnosed as cognitively unimpaired (CU, N = 81, 71.15 ±7.73 yrs, 63 F), mild cognitive impairment (MCI, N = 35, 72.1±7.84 yrs, 17 F) or Alzheimer’s disease (AD, N = 16, 69.45 ± 9.10 yrs, 8 F).
In our whole‐brain neuronal activity model, the individual regional Aβ and tau burdens mediate neuronal...
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Full title
Aβ‐ and Tau‐Mediated Neuronal Excitability Derived from fMRI Predicts Grey Matter Atrophy in Alzheimer’s Disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709396
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709396
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ISSN
1552-5260
E-ISSN
1552-5279
DOI
10.1002/alz.090349
