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Aβ‐ and Tau‐Mediated Neuronal Excitability Derived from fMRI Predicts Grey Matter Atrophy in Alzheim...

Aβ‐ and Tau‐Mediated Neuronal Excitability Derived from fMRI Predicts Grey Matter Atrophy in Alzheim...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709396

Aβ‐ and Tau‐Mediated Neuronal Excitability Derived from fMRI Predicts Grey Matter Atrophy in Alzheimer’s Disease

About this item

Full title

Aβ‐ and Tau‐Mediated Neuronal Excitability Derived from fMRI Predicts Grey Matter Atrophy in Alzheimer’s Disease

Publisher

Hoboken: John Wiley and Sons Inc

Journal title

Alzheimer's & dementia, 2024-12, Vol.20 (S1), p.n/a

Language

English

Formats

Publication information

Publisher

Hoboken: John Wiley and Sons Inc

Subjects

More information

Scope and Contents

Contents

Background
Despite amyloid‐β (Aβ) plaques and tau neurofibrillary tangles being recognized as major Alzheimer’s Disease (AD) hallmarks, their synergistic contribution to neuronal activity remains unclear. We developed a neuroimaging‐based personalized brain activity model to assess the in‐vivo functional impact of AD pathophysiology. In previous reports, model‐inferred neuronal excitability predicted disease progression (i.e., cognitive performance and certain biological markers) [1,2]. Here, we investigate its relationship with brain tissue atrophy.
Method
We used Aβ and tau PET scans, structural T1‐weighted 3D MRI and resting‐state functional MRI from 132 subjects in the TRIAD cohort (https://triad.tnl‐mcgill.com/, Fig. 1a). The participants were diagnosed as cognitively unimpaired (CU, N = 81, 71.15 ±7.73 yrs, 63 F), mild cognitive impairment (MCI, N = 35, 72.1±7.84 yrs, 17 F) or Alzheimer’s disease (AD, N = 16, 69.45 ± 9.10 yrs, 8 F).
In our whole‐brain neuronal activity model, the individual regional Aβ and tau burdens mediate neuronal...

Alternative Titles

Full title

Aβ‐ and Tau‐Mediated Neuronal Excitability Derived from fMRI Predicts Grey Matter Atrophy in Alzheimer’s Disease

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709396

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709396

Other Identifiers

ISSN

1552-5260

E-ISSN

1552-5279

DOI

10.1002/alz.090349

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