Chimeric hippocampal organotypic slices enable the in vitro investigation of human iPSC‐derived micr...
Chimeric hippocampal organotypic slices enable the in vitro investigation of human iPSC‐derived microglia in a three‐dimensional environment with preserved neural network activity
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Publisher
Hoboken: John Wiley and Sons Inc
Journal title
Language
English
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Publisher
Hoboken: John Wiley and Sons Inc
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Background
Microglial cells have emerged as key players in the pathogenesis of Alzheimer’s disease (AD). They act as a first line defense and fulfil a crucial role during brain development and circuit homeostasis. Microglia are involved in the removal of debris, control neural activity, regulate synaptic plasticity, and synapse pruning. Normal m...
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Full title
Chimeric hippocampal organotypic slices enable the in vitro investigation of human iPSC‐derived microglia in a three‐dimensional environment with preserved neural network activity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709818
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709818
Other Identifiers
ISSN
1552-5260
E-ISSN
1552-5279
DOI
10.1002/alz.088649
