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Chimeric hippocampal organotypic slices enable the in vitro investigation of human iPSC‐derived micr...

Chimeric hippocampal organotypic slices enable the in vitro investigation of human iPSC‐derived micr...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709818

Chimeric hippocampal organotypic slices enable the in vitro investigation of human iPSC‐derived microglia in a three‐dimensional environment with preserved neural network activity

About this item

Full title

Chimeric hippocampal organotypic slices enable the in vitro investigation of human iPSC‐derived microglia in a three‐dimensional environment with preserved neural network activity

Publisher

Hoboken: John Wiley and Sons Inc

Journal title

Alzheimer's & dementia, 2024-12, Vol.20 (S1), p.n/a

Language

English

Formats

Publication information

Publisher

Hoboken: John Wiley and Sons Inc

Subjects

More information

Scope and Contents

Contents

Background
Microglial cells have emerged as key players in the pathogenesis of Alzheimer’s disease (AD). They act as a first line defense and fulfil a crucial role during brain development and circuit homeostasis. Microglia are involved in the removal of debris, control neural activity, regulate synaptic plasticity, and synapse pruning. Normal m...

Alternative Titles

Full title

Chimeric hippocampal organotypic slices enable the in vitro investigation of human iPSC‐derived microglia in a three‐dimensional environment with preserved neural network activity

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709818

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11709818

Other Identifiers

ISSN

1552-5260

E-ISSN

1552-5279

DOI

10.1002/alz.088649

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