BRAF V600E and Non-V600E Mutations in RAS Wild-Type Metastatic Colorectal Cancer: Prognostic and The...
BRAF V600E and Non-V600E Mutations in RAS Wild-Type Metastatic Colorectal Cancer: Prognostic and Therapeutic Insights from a Nationwide, Multicenter, Observational Study (J-BROS)
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Author / Creator
Taniguchi, Hiroya , Uehara, Kay , Ishikawa, Toshiaki , Okochi, Osamu , Akazawa, Naoya , Okuda, Hiroyuki , Hasegawa, Hiroko , Shiozawa, Manabu , Kataoka, Masato , Satake, Hironaga , Shimura, Takaya , Kondoh, Chihiro , Kuramochi, Hidekazu , Matsumoto, Toshihiko , Takegawa, Naoki , Yamaguchi, Toshifumi , Nagase, Michitaka , Nakamura, Masato , Takano, Nao , Fujita, Hideto , Watanabe, Takanori , Nishina, Tomohiro , Sakamoto, Yasuhiro , Moriwaki, Toshikazu , Ohori, Hisatsugu , Nakanishi, Masayoshi , Kito, Yosuke , Utsunomiya, Setsuo , Ishikawa, Takeshi , Manaka, Dai , Matsuoka, Hiroshi , Suto, Takeshi , Arai, Toshiyuki , Shinzaki, Shinichiro , Funakoshi, Tohru , Nakayama, Goro , Negoro, Yuji , Tsuji, Yasushi , Makiyama, Akitaka , Takuma, Kunio , Arimoto, Atsuki , Shinozaki, Katsunori , Mishima, Ayako and Masuishi, Toshiki
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Switzerland: MDPI AG
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Scope and Contents
Contents
BRAF mutations occur in 5-10% of metastatic colorectal cancer (mCRC) cases, but their implications for prognosis and optimal treatment remain unclear.
This multicenter, prospective observational study analyzed 377 RAS wild-type cases from 511 patients across 32 centers, using PCR-based methods.
BRAF mutations were identified in 21% (79/377) o...
Alternative Titles
Full title
BRAF V600E and Non-V600E Mutations in RAS Wild-Type Metastatic Colorectal Cancer: Prognostic and Therapeutic Insights from a Nationwide, Multicenter, Observational Study (J-BROS)
Authors, Artists and Contributors
Author / Creator
Uehara, Kay
Ishikawa, Toshiaki
Okochi, Osamu
Akazawa, Naoya
Okuda, Hiroyuki
Hasegawa, Hiroko
Shiozawa, Manabu
Kataoka, Masato
Satake, Hironaga
Shimura, Takaya
Kondoh, Chihiro
Kuramochi, Hidekazu
Matsumoto, Toshihiko
Takegawa, Naoki
Yamaguchi, Toshifumi
Nagase, Michitaka
Nakamura, Masato
Takano, Nao
Fujita, Hideto
Watanabe, Takanori
Nishina, Tomohiro
Sakamoto, Yasuhiro
Moriwaki, Toshikazu
Ohori, Hisatsugu
Nakanishi, Masayoshi
Kito, Yosuke
Utsunomiya, Setsuo
Ishikawa, Takeshi
Manaka, Dai
Matsuoka, Hiroshi
Suto, Takeshi
Arai, Toshiyuki
Shinzaki, Shinichiro
Funakoshi, Tohru
Nakayama, Goro
Negoro, Yuji
Tsuji, Yasushi
Makiyama, Akitaka
Takuma, Kunio
Arimoto, Atsuki
Shinozaki, Katsunori
Mishima, Ayako
Masuishi, Toshiki
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11815755
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11815755
Other Identifiers
ISSN
2072-6694
E-ISSN
2072-6694
DOI
10.3390/cancers17030399
