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Aneuploidy of specific chromosomes is beneficial to cells lacking spindle checkpoint protein Bub3

Aneuploidy of specific chromosomes is beneficial to cells lacking spindle checkpoint protein Bub3

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11819610

Aneuploidy of specific chromosomes is beneficial to cells lacking spindle checkpoint protein Bub3

About this item

Full title

Aneuploidy of specific chromosomes is beneficial to cells lacking spindle checkpoint protein Bub3

Publisher

United States: Public Library of Science

Journal title

PLoS genetics, 2025-02, Vol.21 (2), p.e1011576

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Aneuploidy typically poses challenges for cell survival and growth. However, recent studies have identified exceptions where aneuploidy is beneficial for cells with mutations in certain regulatory genes. Our research reveals that cells lacking the spindle checkpoint gene BUB3 exhibit aneuploidy of select chromosomes. While the spindle checkpoint is...

Alternative Titles

Full title

Aneuploidy of specific chromosomes is beneficial to cells lacking spindle checkpoint protein Bub3

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11819610

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11819610

Other Identifiers

ISSN

1553-7404,1553-7390

E-ISSN

1553-7404

DOI

10.1371/journal.pgen.1011576

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