Targeting the ceramidase ACER3 attenuates cholestasis in mice by mitigating bile acid overload via u...
Targeting the ceramidase ACER3 attenuates cholestasis in mice by mitigating bile acid overload via unsaturated ceramide-mediated LXRβ signaling transduction
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Author / Creator
Liao, Leyi , Liu, Ziying , Liu, Lei , Huang, Can , Li, Yiyi , Mao, Cungui , Xu, Ruijuan , Liu, Haiqing , Liu, Cuiting , Peng, Yonghong , Lei, Tingying , Liang, Hanbiao , Yu, Sheng , Qian, Jianping , Wu, Xianqiu , Wang, Biao , Lin, Yixiong , Zhou, Jie , Li, Qingping , Li, Chuanjiang and Wang, Kai
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Bile acid overload critically drives the pathogenesis of cholestatic liver injury (CLI). While ceramide metabolism has garnered increasing interest in liver research, the role of ceramides in CLI remains unclear. This study investigates the function of alkaline ceramidase 3 (ACER3)-catalyzed hydrolysis of unsaturated ceramides in CLI. Using clinica...
Alternative Titles
Full title
Targeting the ceramidase ACER3 attenuates cholestasis in mice by mitigating bile acid overload via unsaturated ceramide-mediated LXRβ signaling transduction
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11873283
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11873283
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-57330-7
