Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region
Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region
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Chichester, UK: John Wiley & Sons, Ltd
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Language
English
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Chichester, UK: John Wiley & Sons, Ltd
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Contents
The aspartyl protease BACE1 has a pivotal role in the pathogenesis of Alzheimer's disease. Recently, it was shown that in Alzheimer's disease patients, BACE1 levels were elevated although mRNA levels were not changed compared with controls. Here, we demonstrate that the 5′‐untranslated region (5′UTR) of BACE1 controls the rate of BACE1 translation....
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Full title
Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1299076
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1299076
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ISSN
1469-221X
E-ISSN
1469-3178,1469-221X
DOI
10.1038/sj.embor.7400166
