Crystal Structure of Human Indoleamine 2,3-Dioxygenase: Catalytic Mechanism of O₂ Incorporation by a...
Crystal Structure of Human Indoleamine 2,3-Dioxygenase: Catalytic Mechanism of O₂ Incorporation by a Heme-Containing Dioxygenase
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Human indoleamine 2,3-dioxygenase (IDO) catalyzes the cleavage of the pyrrol ring of L-Trp and incorporates both atoms of a molecule of oxygen (O₂). Here we report on the x-ray crystal structure of human IDO, complexed with the ligand inhibitor 4-phenylimidazole and cyanide. The overall structure of IDO shows two a-helical domains with the heme bet...
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Full title
Crystal Structure of Human Indoleamine 2,3-Dioxygenase: Catalytic Mechanism of O₂ Incorporation by a Heme-Containing Dioxygenase
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1413787
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1413787
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0508996103
