Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
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Author / Creator
Radde, Rebecca , Bolmont, Tristan , Kaeser, Stephan A , Coomaraswamy, Janaky , Lindau, Dennis , Stoltze, Lars , Calhoun, Michael E , Jäggi, Fabienne , Wolburg, Hartwig , Gengler, Simon , Haass, Christian , Ghetti, Bernardino , Czech, Christian , Hölscher, Christian , Mathews, Paul M and Jucker, Mathias
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Contents
We have generated a novel transgenic mouse model on a C57BL/6J genetic background that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated presenilin 1 under the control of a neuron‐specific Thy1 promoter element (APPPS1 mice). Cerebral amyloidosis starts at 6–8 weeks and the ratio of human amyloid (A)β42 to Aβ40 is 1.5 and...
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Full title
Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1559665
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1559665
Other Identifiers
ISSN
1469-221X
E-ISSN
1469-3178
DOI
10.1038/sj.embor.7400784
