Crystal Structure and Catalytic Mechanism of the LPS 3-O-Deacylase PagL from Pseudomonas aeruginosa
Crystal Structure and Catalytic Mechanism of the LPS 3-O-Deacylase PagL from Pseudomonas aeruginosa
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Pathogenic Gram-negative bacteria can modify the lipid A portion of their lipopolysaccharide in response to environmental stimuli. 3-O-deacylation of lipid A by the outer membrane enzyme PagL modulates signaling through Toll-like receptor 4, leading to a reduced host immune response. We found that PagL is widely disseminated among Gram-negative bac...
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Full title
Crystal Structure and Catalytic Mechanism of the LPS 3-O-Deacylase PagL from Pseudomonas aeruginosa
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1564273
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1564273
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0509392103
