Heterologous desensitization of the sphingosine‐1‐phosphate receptors by purinoceptor activation in...
Heterologous desensitization of the sphingosine‐1‐phosphate receptors by purinoceptor activation in renal mesangial cells
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Language
English
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Contents
Sphingosine‐1‐phosphate (S1P) is considered a potent mitogen for mesangial cells and activates the classical mitogen‐activated protein kinase (MAPK) cascade via S1P receptors. In this study, we show that S1P signalling is rapidly desensitized upon S1P receptor activation. A complete loss of S1P sensitivity occurs after 10 min of S1P pretreatment an...
Alternative Titles
Full title
Heterologous desensitization of the sphingosine‐1‐phosphate receptors by purinoceptor activation in renal mesangial cells
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1575433
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1575433
Other Identifiers
ISSN
0007-1188
E-ISSN
1476-5381
DOI
10.1038/sj.bjp.0705980
