Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706...
Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706375
About this item
Full title
Author / Creator
Douglas, Stephen A , Behm, David J , Aiyar, Nambi V , Naselsky, Diane , Disa, Jyoti , Brooks, David P , Ohlstein, Eliot H , Gleason, John G , Sarau, Henry M , Foley, James J , Buckley, Peter T , Schmidt, Dulcie B , Wixted, William E , Widdowson, Katherine , Riley, Graham , Jin, Jian , Gallagher, Timothy F , Schmidt, Stanley J , Ridgers, Lance , Christmann, Lisa T , Keenan, Richard M , Knight, Steven D and Dhanak, Dashyant
Publisher
Oxford, UK: Blackwell Publishing Ltd
Journal title
Language
English
Formats
Publication information
Publisher
Oxford, UK: Blackwell Publishing Ltd
Subjects
More information
Scope and Contents
Contents
1
SB‐706375 potently inhibited [125I]hU‐II binding to both mammalian recombinant and ‘native’ UT receptors (Ki 4.7±1.5 to 20.7±3.6 nM at rodent, feline and primate recombinant UT receptors and Ki 5.4±0.4 nM at the endogenous UT receptor in SJRH30 cells).
2
Prior exposure to SB‐706375 (1 μM, 30 min) did not alter [125I]hU‐II binding affinit...
Alternative Titles
Full title
Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706375
Authors, Artists and Contributors
Author / Creator
Behm, David J
Aiyar, Nambi V
Naselsky, Diane
Disa, Jyoti
Brooks, David P
Ohlstein, Eliot H
Gleason, John G
Sarau, Henry M
Foley, James J
Buckley, Peter T
Schmidt, Dulcie B
Wixted, William E
Widdowson, Katherine
Riley, Graham
Jin, Jian
Gallagher, Timothy F
Schmidt, Stanley J
Ridgers, Lance
Christmann, Lisa T
Keenan, Richard M
Knight, Steven D
Dhanak, Dashyant
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1576177
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1576177
Other Identifiers
ISSN
0007-1188
E-ISSN
1476-5381
DOI
10.1038/sj.bjp.0706229
