New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse mode...
New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Language
English
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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We previously reported that the compound O‐2093 is a selective inhibitor of the reuptake of the endocannabinoid anandamide (AEA). We have now re‐examined the activity of O‐2093 in vivo and synthesized four structural analogs (O‐2247, O‐2248, O‐3246, and O‐3262), whose activity was assessed in: (a) binding assays carried out with membranes from cell...
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Full title
New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1615845
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1615845
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ISSN
0007-1188
E-ISSN
1476-5381
DOI
10.1038/sj.bjp.0706418
