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The endocannabinoid system and its therapeutic exploitation
Author / Creator:Marzo, Vincenzo Di ; Bifulco, Maurizio ; Petrocellis, Luciano De
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2004-09, Vol.3 (9), p.771-784
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Why do cannabinoid receptors have more than one endogenous ligand?
Author / Creator:Di Marzo, Vincenzo ; De Petrocellis, Luciano
Publisher:England: The Royal Society
Journal title:Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2012-12, Vol.367 (1607), p.3216-3228
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Leucettamols, bifunctionalized marine sphingoids, act as modulators of TRPA1 and TRPM8 channels
Author / Creator:Chianese, Giuseppina ; Fattorusso, Ernesto ; Putra, Masteria Yunovilsa ; Calcinai, Barbara ; Bavestrello, Giorgio ; Moriello, Aniello Schiano ; De Petrocellis, Luciano ; Di Marzo, Vincenzo ; Taglialatela-Scafati, Orazio
Publisher:Switzerland: MDPI AG
Journal title:Marine drugs, 2012-11, Vol.10 (11), p.2435-2447
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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Author / Creator:Soethoudt, Marjolein ; Grether, Uwe ; Fingerle, Jürgen ; Grim, Travis W. ; Fezza, Filomena ; de Petrocellis, Luciano ; Ullmer, Christoph ; Rothenhäusler, Benno ; Perret, Camille ; van Gils, Noortje ; Finlay, David ; MacDonald, Christa ; Chicca, Andrea ; Gens, Marianela Dalghi ; Stuart, Jordyn ; de Vries, Henk ; Mastrangelo, Nicolina ; Xia, Lizi ; Alachouzos, Georgios ; Baggelaar, Marc P. ; Martella, Andrea ; Mock, Elliot D. ; Deng, Hui ; Heitman, Laura H. ; Connor, Mark ; Di Marzo, Vincenzo ; Gertsch, Jürg ; Lichtman, Aron H. ; Maccarrone, Mauro ; Pacher, Pal ; Glass, Michelle ; van der Stelt, Mario
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-01, Vol.8 (1), p.13958-14, Article 13958
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Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
Author / Creator:van Esbroeck, Annelot C. M. ; Janssen, Antonius P. A. ; Cognetta, Armand B. ; Ogasawara, Daisuke ; Shpak, Guy ; van der Kroeg, Mark ; Kantae, Vasudev ; Baggelaar, Marc P. ; de Vrij, Femke M. S. ; Deng, Hui ; Allarà, Marco ; Fezza, Filomena ; Lin, Zhanmin ; van der Wel, Tom ; Soethoudt, Marjolein ; Mock, Elliot D. ; den Dulk, Hans ; Baak, Ilse L. ; Florea, Bogdan I. ; Hendriks, Giel ; De Petrocellis, Luciano ; Overkleeft, Herman S. ; Hankemeier, Thomas ; De Zeeuw, Chris I. ; Di Marzo, Vincenzo ; Maccarrone, Mauro ; Cravatt, Benjamin F. ; Kushner, Steven A. ; van der Stelt, Mario
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-06, Vol.356 (6342), p.1084-1087
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Non-CB1, Non-CB2 Receptors for Endocannabinoids, Plant Cannabinoids, and Synthetic Cannabimimetics: Focus on G-protein-coupled Receptors and Transient Receptor Potential Channels
Author / Creator:De Petrocellis, Luciano ; Di Marzo, Vincenzo
Publisher:Boston: Springer US
Journal title:Journal of neuroimmune pharmacology, 2010-03, Vol.5 (1), p.103-121
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Moringin, A Stable Isothiocyanate from Moringa oleifera , Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro
Author / Creator:Borgonovo, Gigliola ; De Petrocellis, Luciano ; Schiano Moriello, Aniello ; Bertoli, Simona ; Leone, Alessandro ; Battezzati, Alberto ; Mazzini, Stefania ; Bassoli, Angela
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-02, Vol.25 (4), p.976
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Indole-2-Carboxamide as an Effective Scaffold for the Design of New TRPV1 Agonists
Author / Creator:Maramai, Samuele ; Mugnaini, Claudia ; Paolino, Marco ; Schiano Moriello, Aniello ; De Petrocellis, Luciano ; Corelli, Federico ; Aiello, Francesca ; Brizzi, Antonella
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2025-02, Vol.30 (3), p.721
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Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1
Author / Creator:Stock, Kristin ; Kumar, Jitender ; Synowitz, Michael ; Petrosino, Stefania ; Imperatore, Roberta ; Smith, Ewan St J ; Wend, Peter ; Purfürst, Bettina ; Nuber, Ulrike A ; Gurok, Ulf ; Matyash, Vitali ; Wälzlein, Joo-Hee ; Chirasani, Sridhar R ; Dittmar, Gunnar ; Cravatt, Benjamin F ; Momma, Stefan ; Lewin, Gary R ; Ligresti, Alessia ; De Petrocellis, Luciano ; Cristino, Luigia ; Di Marzo, Vincenzo ; Kettenmann, Helmut ; Glass, Rainer
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2012-08, Vol.18 (8), p.1232-1238
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Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism
Author / Creator:Starowicz, Katarzyna ; Makuch, Wioletta ; Korostynski, Michal ; Malek, Natalia ; Slezak, Michal ; Zychowska, Magdalena ; Petrosino, Stefania ; De Petrocellis, Luciano ; Cristino, Luigia ; Przewlocka, Barbara ; Di Marzo, Vincenzo
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-04, Vol.8 (4), p.e60040-e60040
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Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa , as a Novel PPARγ Agonist via a Combined Computational and Functional Study
Author / Creator:Iannotti, Fabio Arturo ; De Maio, Fabrizia ; Panza, Elisabetta ; Appendino, Giovanni ; Taglialatela-Scafati, Orazio ; De Petrocellis, Luciano ; Amodeo, Pietro ; Vitale, Rosa Maria
Publisher:Switzerland: MDPI
Journal title:Molecules (Basel, Switzerland), 2020-03, Vol.25 (5), p.1119
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Isothiocyanates and Glucosinolates from Sisymbrium officinale (L.) Scop. ("the Singers' Plant"): Isolation and in Vitro Assays on the Somatosensory and Pain Receptor TRPA1 Channel
Author / Creator:Borgonovo, Gigliola ; Zimbaldi, Nathan ; Guarise, Marta ; De Nisi, Patrizia ; De Petrocellis, Luciano ; Schiano Moriello, Aniello ; Bassoli, Angela
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2019-03, Vol.24 (5), p.949
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Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes
Author / Creator:Mazzotta, Sarah ; Carullo, Gabriele ; Schiano Moriello, Aniello ; Amodeo, Pietro ; Di Marzo, Vincenzo ; Vega-Holm, Margarita ; Vitale, Rosa Maria ; Aiello, Francesca ; Brizzi, Antonella ; De Petrocellis, Luciano
Publisher:Switzerland: MDPI AG
Journal title:Marine drugs, 2020-10, Vol.18 (10), p.519
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The Endocannabinoid System and Pivotal Role of the CB₂ Receptor in Mouse Spermatogenesis
Author / Creator:Grimaldi, Paola ; Orlando, Pierangelo ; Di Siena, Sara ; Lolicato, Francesca ; Petrosino, Stefania ; Bisogno, Tiziana ; Geremia, Raffaele ; De Petrocellis, Luciano ; Di Marzo, Vincenzo ; Yanagimachi, Ryuzo
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-07, Vol.106 (27), p.11131-11136
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Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation
Author / Creator:Vitale, Rosa Maria ; Iannotti, Fabio Arturo ; Schiano Moriello, Aniello ; Tunisi, Lea ; Piscitelli, Fabiana ; Savopoulos, Ranjev ; Cristino, Luigia ; De Petrocellis, Luciano ; Amodeo, Pietro ; Gray, Roy ; Di Marzo, Vincenzo
Publisher:Switzerland: MDPI AG
Journal title:Biomolecules (Basel, Switzerland), 2021-08, Vol.11 (8), p.1134
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TRPA1 Modulating C14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba
Author / Creator:Chianese, Giuseppina ; Sirignano, Carmina ; Shokoohinia, Yalda ; Mohammadi, Zeynab ; Bazvandi, Leili ; Jafari, Fataneh ; Jalilian, Fereshteh ; Schiano Moriello, Aniello ; De Petrocellis, Luciano ; Taglialatela-Scafati, Orazio ; Rigano, Daniela
Publisher:Basel: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2018-07, Vol.23 (7), p.1750
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An Endogenous Capsaicin-like Substance with High Potency at Recombinant and Native Vanilloid VR1 Receptors
Author / Creator:Huang, Susan M. ; Bisogno, Tiziana ; Trevisani, Marcello ; Al-Hayani, Abdulmonem ; De Petrocellis, Luciano ; Fezza, Filomena ; Tognetto, Michele ; Petros, Timothy J. ; Krey, Jocelyn F. ; Chu, Constance J. ; Miller, Jeffrey D. ; Davies, Stephen N. ; Geppetti, Pierangelo ; Walker, J. Michael ; Di Marzo, Vincenzo
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2002-06, Vol.99 (12), p.8400-8405
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The Combined Effect of Branching and Elongation on the Bioactivity Profile of Phytocannabinoids. Part I: Thermo-TRPs
Author / Creator:Mattoteia, Daiana ; Schiano Moriello, Aniello ; Taglialatela-Scafati, Orazio ; Amodeo, Pietro ; De Petrocellis, Luciano ; Appendino, Giovanni ; Vitale, Rosa Maria ; Caprioglio, Diego
Publisher:Basel: MDPI AG
Journal title:Biomedicines, 2021-08, Vol.9 (8), p.1070
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A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator
Author / Creator:Manzo, Emiliano ; Schiano Moriello, Aniello ; Tinto, Francesco ; Verde, Roberta ; Allarà, Marco ; De Petrocellis, Luciano ; Pagano, Ester ; Izzo, Angelo A ; Di Marzo, Vincenzo ; Petrosino, Stefania
Publisher:Switzerland: MDPI
Journal title:Cells (Basel, Switzerland), 2021-02, Vol.10 (2), p.450
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The Endogenous Cannabinoid Anandamide Inhibits Human Breast Cancer Cell Proliferation
Author / Creator:De Petrocellis, Luciano ; Melck, Dominique ; Palmisano, Antonella ; Bisogno, Tiziana ; Laezza, Chiara ; Bifulco, Maurizio ; Di Marzo, Vincenzo
Publisher:United States: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1998-07, Vol.95 (14), p.8375-8380
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The endocannabinoid system and its therapeutic exploitation

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Why do cannabinoid receptors have more than one endogenous ligand?

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Leucettamols, bifunctionalized marine sphingoids, act as modulators of TRPA1 and TRPM8 channels

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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

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Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

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Non-CB1, Non-CB2 Receptors for Endocannabinoids, Plant Cannabinoids, and Synthetic Cannabimimetics: Focus on G-protein-coupled Receptors and Transient Receptor Potential Channels

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Moringin, A Stable Isothiocyanate from Moringa oleifera , Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

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Indole-2-Carboxamide as an Effective Scaffold for the Design of New TRPV1 Agonists

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Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

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Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism

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Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa , as a Novel PPARγ Agonist via a Combined Computational and Functional Study

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Isothiocyanates and Glucosinolates from Sisymbrium officinale (L.) Scop. ("the Singers' Plant"): Isolation and in Vitro Assays on the Somatosensory and Pain Receptor TRPA1 Channel

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Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes

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The Endocannabinoid System and Pivotal Role of the CB₂ Receptor in Mouse Spermatogenesis

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Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation

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TRPA1 Modulating C14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba

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An Endogenous Capsaicin-like Substance with High Potency at Recombinant and Native Vanilloid VR1 Receptors

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The Combined Effect of Branching and Elongation on the Bioactivity Profile of Phytocannabinoids. Part I: Thermo-TRPs

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A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator

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The Endogenous Cannabinoid Anandamide Inhibits Human Breast Cancer Cell Proliferation

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