Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pat...
Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pathway
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Contents
Upon DNA damage, a complex called the PIDDosome is formed and either signals NF‐κB activation and thus cell survival or alternatively triggers caspase‐2 activation and apoptosis. PIDD (p53‐induced protein with a death domain) is constitutively processed giving rise to a 48‐kDa N‐terminal fragment containing the leucine‐rich repeats (LRRs, PIDD‐N) a...
Alternative Titles
Full title
Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1782377
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1782377
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/sj.emboj.7601473
