Lethal recessive myelin toxicity of prion protein lacking its central domain
Lethal recessive myelin toxicity of prion protein lacking its central domain
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Author / Creator
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publication information
Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
PrP
C
‐deficient mice expressing prion protein variants with large amino‐proximal deletions (termed PrP
ΔF
) suffer from neurodegeneration, which is rescued by full‐length PrP
C
. We now report that expression of PrP
ΔCD
, a PrP variant lacking 40 central residues (94–134), induces a rapidly progressive, lethal phenotype wit...
Alternative Titles
Full title
Lethal recessive myelin toxicity of prion protein lacking its central domain
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1783444
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1783444
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/sj.emboj.7601510
