A Phenylalanine Clamp Catalyzes Protein Translocation through the Anthrax Toxin Pore
A Phenylalanine Clamp Catalyzes Protein Translocation through the Anthrax Toxin Pore
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Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Scope and Contents
Contents
The protective antigen component of anthrax toxin forms a homoheptameric pore in the endosomal membrane, creating a narrow passageway for the enzymatic components of the toxin to enter the cytosol. We found that, during conversion of the heptameric precursor to the pore, the seven phenylalanine-427 residues converged within the lumen, generating a...
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Full title
A Phenylalanine Clamp Catalyzes Protein Translocation through the Anthrax Toxin Pore
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1815389
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1815389
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1113380
