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Melnyk, Roman A
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: MEL-OCK, 2022, p.7666-7666
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Melnyk, Roman A
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: LIU-MEM, 2021, p.7639-7639
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bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)
Author / Creator:Lim, Shuhui ; Khoo, Regina ; Peh, Khong Ming ; Teo, Jinkai ; Chang, Shih Chieh ; Ng, Simon ; Beilhartz, Greg L. ; Melnyk, Roman A. ; Johannes, Charles W. ; Brown, Christopher J. ; Lane, David P. ; Henry, Brian ; Partridge, Anthony W.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (11), p.5791-5800
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Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
Author / Creator:Tam, John ; Hamza, Therwa ; Ma, Bing ; Chen, Kevin ; Beilhartz, Greg L. ; Ravel, Jacques ; Feng, Hanping ; Melnyk, Roman A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-12, Vol.9 (1), p.5233-11, Article 5233
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The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus
Author / Creator:Orrell, Kathleen E. ; Mansfield, Michael J. ; Doxey, Andrew C. ; Melnyk, Roman A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-01, Vol.11 (1), p.432-432, Article 432
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An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies
Author / Creator:Gill, Shivneet K ; Sugiman-Marangos, Seiji N ; Beilhartz, Greg L ; Mei, Elizabeth ; Taipale, Mikko ; Melnyk, Roman A
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2024-10, Vol.16 (10), p.2638-2651
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The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis
Author / Creator:Bilverstone, Terry W. ; Garland, Megan ; Cave, Rory J. ; Kelly, Michelle L. ; Tholen, Martina ; Bouley, Donna M. ; Kaye, Philip ; Minton, Nigel P. ; Bogyo, Matthew ; Kuehne, Sarah A. ; Melnyk, Roman A.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2020-09, Vol.16 (9), p.e1008852
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Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore
Author / Creator:Zhang, Zhifen ; Park, Minyoung ; Tam, John ; Auger, Anick ; Beilhartz, Greg L. ; Lacy, D. Borden ; Melnyk, Roman A.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (10), p.3721-3726
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Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold
Author / Creator:Sugiman-Marangos, Seiji N. ; Gill, Shivneet K. ; Mansfield, Michael J. ; Orrell, Kathleen E. ; Doxey, Andrew C. ; Melnyk, Roman A.
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2022-04, Vol.5 (1), p.375-375, Article 375
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A Phenylalanine Clamp Catalyzes Protein Translocation through the Anthrax Toxin Pore
Author / Creator:Krantz, Bryan A. ; Melnyk, Roman A. ; Zhang, Sen ; Juris, Stephen J. ; Lacy, D. Borden ; Wu, Zhengyan ; Finkelstein, Alan ; Collier, R. John
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2005-07, Vol.309 (5735), p.777-781
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Structure of Heptameric Protective Antigen Bound to an Anthrax Toxin Receptor: A Role for Receptor in pH-Dependent Pore Formation
Author / Creator:Lacy, D. Borden ; Wigelsworth, Darran J. ; Melnyk, Roman A. ; Harrison, Stephen C. ; Collier, R. John
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2004-09, Vol.101 (36), p.13147-13151
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ArticlesPeer ReviewedFull Text
A Loop Network within the Anthrax Toxin Pore Positions the Phenylalanine Clamp in an Active Conformation
Author / Creator:Melnyk, Roman A. ; Collier, R. John
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2006-06, Vol.103 (26), p.9802-9807
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Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants
Author / Creator:Gorman, Paul M ; Kim, Sanguk ; Guo, Meng ; Melnyk, Roman A ; McLaurin, Joanne ; Fraser, Paul E ; Bowie, James U ; Chakrabartty, Avijit
Publisher:England: BioMed Central Ltd
Journal title:BMC neuroscience, 2008-01, Vol.9 (1), p.17-17, Article 17
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Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin
Author / Creator:Tam, John ; Icho, Simoun ; Utama, Evelyn ; Orrell, Kathleen E. ; Gómez-Biagi, Rodolfo F. ; Theriot, Casey M. ; Kroh, Heather K. ; Rutherford, Stacey A. ; Lacy, D. Borden ; Melnyk, Roman A.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (12), p.6792-6800
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An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth
Author / Creator:Vidimar, Vania ; Beilhartz, Greg L. ; Park, Minyoung ; Biancucci, Marco ; Kieffer, Matthew B. ; Gius, David R. ; Melnyk, Roman A. ; Satchell, Karla J. F.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (29), p.16938-16948
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A Model of Anthrax Toxin Lethal Factor Bound to Protective Antigen
Author / Creator:Lacy, D. Borden ; Lin, Henry C. ; Melnyk, Roman A. ; Schueler-Furman, Ora ; Laura Reither ; Cunningham, Kristina ; Baker, David ; Collier, R. John
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2005-11, Vol.102 (45), p.16409-16414
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Renin and Prorenin Activate Pathways Implicated in Organ Damage in Human Mesangial Cells Independent of Angiotensin II Production
Author / Creator:Melnyk, Roman A. ; Tam, John ; Boie, Yves ; Kennedy, Brian P. ; Percival, M. David
Publisher:Basel, Switzerland: S. Karger AG
Journal title:American journal of nephrology, 2009-01, Vol.30 (3), p.232-243
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ArticlesPeer ReviewedFull Text
Defective mutations within the translocation domain of Clostridium difficile toxin B impair disease pathogenesis
Author / Creator:Hamza, Therwa ; Zhang, Zhifen ; Melnyk, Roman A. ; Feng, Hanping
Publisher:United States: Oxford University Press
Journal title:Pathogens and disease, 2016-02, Vol.74 (1), p.ftv098-ftv098
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Crystal structure of Clostridium difficile toxin A
Author / Creator:Chumbler, Nicole M ; Rutherford, Stacey A ; Zhang, Zhifen ; Farrow, Melissa A ; Lisher, John P ; Farquhar, Erik ; Giedroc, David P ; Spiller, Benjamin W ; Melnyk, Roman A ; Lacy, D Borden
Publisher:England
Journal title:Nature microbiology, 2016-01, Vol.1 (1), p.15002
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Crystal structure of Clostridium difficile toxin A
Author / Creator:Chumbler, Nicole M. ; Rutherford, Stacey A. ; Zhang, Zhifen ; Farrow, Melissa A. ; Lisher, John P. ; Farquhar, Erik ; Giedroc, David P. ; Spiller, Benjamin W. ; Melnyk, Roman A. ; Lacy, D. Borden
Publisher:London: Nature Publishing Group UK
Journal title:Nature microbiology, 2016-01, Vol.1 (1), p.15002-15002, Article 15002
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Showing 1 to 20 of 32 results

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Melnyk, Roman A

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Melnyk, Roman A

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bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)

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Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

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The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus

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An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies

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The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis

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Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore

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Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold

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A Phenylalanine Clamp Catalyzes Protein Translocation through the Anthrax Toxin Pore

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Structure of Heptameric Protective Antigen Bound to an Anthrax Toxin Receptor: A Role for Receptor in pH-Dependent Pore Formation

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A Loop Network within the Anthrax Toxin Pore Positions the Phenylalanine Clamp in an Active Conformation

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Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

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Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin

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An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth

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A Model of Anthrax Toxin Lethal Factor Bound to Protective Antigen

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Renin and Prorenin Activate Pathways Implicated in Organ Damage in Human Mesangial Cells Independent of Angiotensin II Production

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Defective mutations within the translocation domain of Clostridium difficile toxin B impair disease pathogenesis

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Crystal structure of Clostridium difficile toxin A

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Crystal structure of Clostridium difficile toxin A

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