Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Parkinson's disease (PD) is characterized by the selective vulnerability of the nigrostriatal dopaminergic circuit. Recently, loss-of-function mutations in the PTEN-induced kinase 1 (PINK1) gene have been linked to early-onset PD. How PINK1 deficiency causes dopaminergic dysfunction and degeneration in PD patients is unknown. Here, we investigate t...
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Full title
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1890561
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1890561
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0702717104
