Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
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Author / Creator
Martinez-Vicente, Marta , Talloczy, Zsolt , Kaushik, Susmita , Massey, Ashish C , Mazzulli, Joseph , Mosharov, Eugene V , Hodara, Roberto , Fredenburg, Ross , Wu, Du-Chu , Follenzi, Antonia , Dauer, William , Przedborski, Serge , Ischiropoulos, Harry , Lansbury, Peter T , Sulzer, David and Cuervo, Ana Maria
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Altered degradation of alpha-synuclein (alpha-syn) has been implicated in the pathogenesis of Parkinson disease (PD). We have shown that alpha-syn can be degraded via chaperone-mediated autophagy (CMA), a selective lysosomal mechanism for degradation of cytosolic proteins. Pathogenic mutants of alpha-syn block lysosomal translocation, impairing the...
Alternative Titles
Full title
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2157565
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2157565
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI32806
