TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model...
TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis
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United States: American Society for Clinical Investigation
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Language
English
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United States: American Society for Clinical Investigation
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Dysfunctional Tregs have been identified in individuals with psoriasis. However, their role in the pathogenesis of the disease remains unclear. Here we explored the effect of diminished CD18 (beta2 integrin) expression on the function of CD4+CD25+CD127(-) Tregs using the Cd18 hypomorphic (Cd18hypo) PL/J mouse model of psoriasis that closely resembl...
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Full title
TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2398739
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2398739
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ISSN
0021-9738
DOI
10.1172/JCI34916
