De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
G9a is involved in gene silencing during early embryonic development, catalyzing the methylation of H3K9, which results in heterochromatinization, and also promoting methylation of DNA
de novo
. These two G9a activities are now dissected, and
de novo
DNA methylation is shown to occur via recruitment of Dnmt3a/3b and to be necessary and...
Alternative Titles
Full title
De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2581722
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2581722
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.1476
