The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
About this item
Full title
Author / Creator
Marchetti, Sandrine , Gamas, Parvati , Belhacène, Nathalie , Grosso, Sebastien , Pradelli, Ludivine A , Colosetti, Pascal , Johansen, Claus , Iversen, Lars , Deckert, Marcel , Luciano, Fréderic , Hofman, Paul , Ortonne, Nicolas , Khemis, Abdallah , Mari, Bernard , Ortonne, Jean-Paul , Ricci, Jean-Ehrland and Auberger, Patrick
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
Formats
Publication information
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Subjects
More information
Scope and Contents
Contents
We showed previously that Lyn is a substrate for caspases, a family of cysteine proteases, involved in the regulation of apoptosis and inflammation. Here, we report that expression of the caspase‐cleaved form of Lyn (LynΔN), in mice, mediates a chronic inflammatory syndrome resembling human psoriasis. Genetic ablation of TNF receptor 1 in a LynΔN b...
Alternative Titles
Full title
The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2735179
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2735179
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2009.183
