Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localizatio...
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents
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Publisher
United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Insulin signaling can be modulated by several isoforms of PKC in peripheral tissues. Here, we assessed whether one specific isoform, PKC-theta, was expressed in critical CNS regions that regulate energy balance and whether it mediated the deleterious effects of diets high in fat, specifically palmitic acid, on hypothalamic insulin activity in rats...
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Full title
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2735917
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2735917
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI36714
