Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing t...
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Systemic delivery remains a major obstacle in therapeutic applications of siRNAs. Using RNA aptamer–siRNA chimeras with enhanced silencing activity and specificity, Dassie
et al
. achieve regression of xenograft prostate tumors by intraperitoneal injection.
Prostate cancer cells expressing prostate-specific membrane antigen (PSMA) have bee...
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Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2791695
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2791695
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.1560
