Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
About this item
Full title
Author / Creator
Dang, Lenny , White, David W. , Gross, Stefan , Bennett, Bryson D. , Bittinger, Mark A. , Driggers, Edward M. , Fantin, Valeria R. , Jang, Hyun Gyung , Jin, Shengfang , Keenan, Marie C. , Marks, Kevin M. , Prins, Robert M. , Ward, Patrick S. , Yen, Katharine E. , Liau, Linda M. , Rabinowitz, Joshua D. , Cantley, Lewis C. , Thompson, Craig B. , Vander Heiden, Matthew G. , Su, Shinsan M. and Brookhaven National Laboratory (BNL) National Synchrotron Light Source
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain cancers. These mutations occur at a single amino acid residue of the IDH1 active site, resulting in loss of the enzyme’s ability to catalyse conversion of isocitrate to α-ketoglutarate. However, only a single copy of the...
Alternative Titles
Full title
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Authors, Artists and Contributors
Author / Creator
White, David W.
Gross, Stefan
Bennett, Bryson D.
Bittinger, Mark A.
Driggers, Edward M.
Fantin, Valeria R.
Jang, Hyun Gyung
Jin, Shengfang
Keenan, Marie C.
Marks, Kevin M.
Prins, Robert M.
Ward, Patrick S.
Yen, Katharine E.
Liau, Linda M.
Rabinowitz, Joshua D.
Cantley, Lewis C.
Thompson, Craig B.
Vander Heiden, Matthew G.
Su, Shinsan M.
Brookhaven National Laboratory (BNL) National Synchrotron Light Source
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2818760
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2818760
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature08617
