Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer
Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer
About this item
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Author / Creator
Liu, Wennuan , Laitinen, Sari , Khan, Sofia , Vihinen, Mauno , Kowalski, Jeanne , Yu, Guoqiang , Chen, Li , Ewing, Charles M , Eisenberger, Mario A , Carducci, Michael A , Nelson, William G , Yegnasubramanian, Srinivasan , Luo, Jun , Wang, Yue , Xu, Jianfeng , Isaacs, William B , Visakorpi, Tapio and Bova, G Steven
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Primary prostate cancer is genomically highly heterogeneous and is thought to derive from multiple independent clones of cancer cells. Using high-resolution genomic analyses, Bova
et al
. now show that, in contrast to primary tumors, metastases are monoclonal, originating from a single cancer cell. These findings call into question current vi...
Alternative Titles
Full title
Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2839160
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2839160
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.1944
