Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1
About this item
Full title
Author / Creator
Hayashi-Takagi, Akiko , Takaki, Manabu , Graziane, Nick , Seshadri, Saurav , Murdoch, Hannah , Dunlop, Allan J , Makino, Yuichi , Seshadri, Anupamaa J , Ishizuka, Koko , Srivastava, Deepak P , Xie, Zhong , Baraban, Jay M , Houslay, Miles D , Tomoda, Toshifumi , Brandon, Nicholas J , Kamiya, Atsushi , Yan, Zhen , Penzes, Peter and Sawa, Akira
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
The number of dendritic spines is reduced in the postmortem brains of individuals with schizophrenia. Revealing a potential mechanism of such change, this study finds that the schizophrenia-associated protein DISC1 regulates the Rho GTPase pathway to modulate dendritic spine size.
Synaptic spines are dynamic structures that regulate neuronal res...
Alternative Titles
Full title
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1
Authors, Artists and Contributors
Author / Creator
Takaki, Manabu
Graziane, Nick
Seshadri, Saurav
Murdoch, Hannah
Dunlop, Allan J
Makino, Yuichi
Seshadri, Anupamaa J
Ishizuka, Koko
Srivastava, Deepak P
Xie, Zhong
Baraban, Jay M
Houslay, Miles D
Tomoda, Toshifumi
Brandon, Nicholas J
Kamiya, Atsushi
Yan, Zhen
Penzes, Peter
Sawa, Akira
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2846623
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2846623
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.2487
