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Rfx6 directs islet formation and insulin production in mice and humans

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Rfx6 directs islet formation and insulin production in mice and humans

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2896718

Rfx6 directs islet formation and insulin production in mice and humans

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London: Nature Publishing Group UK

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Contents

Insulin from the β-cells of the pancreatic islets of Langerhans controls energy homeostasis in vertebrates, and its deficiency causes diabetes mellitus. During embryonic development, the transcription factor neurogenin 3 (Neurog3) initiates the differentiation of the β-cells and other islet cell types from pancreatic endoderm, but the genetic progr...

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Full title

Rfx6 directs islet formation and insulin production in mice and humans

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2896718

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2896718

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature08748

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