Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members
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Author / Creator
Wheeler, D L , Huang, S , Kruser, T J , Nechrebecki, M M , Armstrong, E A , Benavente, S , Gondi, V , Hsu, K-T and Harari, P M
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The epidermal growth factor receptor (EGFR) is a central regulator of proliferation and progression in human cancers. Five EGFR inhibitors, two monoclonal antibodies and three TKIs, have recently gained FDA approval in oncology (cetuximab, panitumumab, erlotinib, gefitinib and lapatinib). These strategies of EGFR inhibition demonstrate major tumor...
Alternative Titles
Full title
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2903615
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2903615
Other Identifiers
ISSN
0950-9232,1476-5594
E-ISSN
1476-5594
DOI
10.1038/onc.2008.19
