Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia
Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
MLL fusions are linked to leukemias and retain the CXXC domain, which binds unmethylated DNA. The NMR structure of CXXC–DNA now indicates the interactions underlying binding. Mutation of a key residue to a nonbinding form decreases proliferation caused by an MLL-AF9 fusion and leukemias induced by MLL-AF9 expression in mice.
The gene
MLL
(...
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Full title
Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2908503
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2908503
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.1714
