Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, No...
Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Interleukin 15 (IL-15) promotes the survival of natural killer (NK) cells by preventing apoptosis through mechanisms unknown at present. Here we identify Bim, Noxa and Mcl-1 as key regulators of IL-15-dependent survival of NK cells. IL-15 suppressed apoptosis by limiting Bim expression through the kinases Erk1 and Erk2 and mechanisms dependent on t...
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Full title
Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2951739
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2951739
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916,1365-2567
DOI
10.1038/ni1487
