CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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It remains uncertain how the DNA sequence of mammalian genes influences the transcriptional response to extracellular signals. Here, we show that the number of CREB‐binding sites (CREs) affects whether the related histone acetyltransferases (HATs) CREB‐binding protein (CBP) and p300 are required for endogenous gene transcription. Fibroblasts with b...
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Full title
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2982758
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2982758
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ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2010.235
