Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites
Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Selective ion conduction across ion channel pores is central to cellular physiology. To understand the underlying principles of ion selectivity in tetrameric cation channels, we engineered a set of cation channel pores based on the nonselective NaK channel and determined their structures to high resolution. These structures showcase an ensemble of...
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Full title
Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3021048
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3021048
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1013636108