Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthe...
Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Contents
Kinetochores assemble on distinct ‘centrochromatin’ containing the histone H3 variant CENP‐A and interspersed nucleosomes dimethylated on H3K4 (H3K4me2). Little is known about how the chromatin environment at active centromeres governs centromeric structure and function. Here, we report that centrochromatin resembles K4–K36 domains found in the bod...
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Full title
Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3025471
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3025471
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ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2010.329
