NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
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Author / Creator
Hirota, Simon A. , Ng, Jeffrey , Lueng, Alan , Khajah, Maitham , Parhar, Ken , Li, Yan , Lam, Victor , Potentier, Mireille S. , Ng, Kelvin , Bawa, Misha , McCafferty, Donna-Marie , Rioux, Kevin P. , Ghosh, Subrata , Xavier, Ramnik J. , Colgan, Sean P. , Tschopp, Jurg , Muruve, Daniel , MacDonald, Justin A. and Beck, Paul L.
Publisher
Oxford, UK: Oxford University Press
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Language
English
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Publisher
Oxford, UK: Oxford University Press
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Contents
Attenuated innate immune responses to the intestinal microbiota have been linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed that hypofunctional mutations of NLRP3, a member of the NOD-like receptor (NLR) superfamily, are associated with an increased risk of developing CD. NLRP3 is a key component of the inflam...
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Full title
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3026862
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3026862
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ISSN
1078-0998,1536-4844
E-ISSN
1536-4844
DOI
10.1002/ibd.21478