NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
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Author / Creator
Hirota, Simon A. , Ng, Jeffrey , Lueng, Alan , Khajah, Maitham , Parhar, Ken , Li, Yan , Lam, Victor , Potentier, Mireille S. , Ng, Kelvin , Bawa, Misha , McCafferty, Donna-Marie , Rioux, Kevin P. , Ghosh, Subrata , Xavier, Ramnik J. , Colgan, Sean P. , Tschopp, Jurg , Muruve, Daniel , MacDonald, Justin A. and Beck, Paul L.
Publisher
Oxford, UK: Oxford University Press
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Language
English
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Publisher
Oxford, UK: Oxford University Press
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Scope and Contents
Contents
Attenuated innate immune responses to the intestinal microbiota have been linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed that hypofunctional mutations of NLRP3, a member of the NOD-like receptor (NLR) superfamily, are associated with an increased risk of developing CD. NLRP3 is a key component of the inflam...
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Full title
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3026862
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3026862
Other Identifiers
ISSN
1078-0998,1536-4844
E-ISSN
1536-4844
DOI
10.1002/ibd.21478
