Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
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Author / Creator
Varela, Ignacio , Tarpey, Patrick , Raine, Keiran , Huang, Dachuan , Ong, Choon Kiat , Stephens, Philip , Davies, Helen , Jones, David , Lin, Meng-Lay , Teague, Jon , Bignell, Graham , Butler, Adam , Cho, Juok , Dalgliesh, Gillian L. , Galappaththige, Danushka , Greenman, Chris , Hardy, Claire , Jia, Mingming , Latimer, Calli , Lau, King Wai , Marshall, John , McLaren, Stuart , Menzies, Andrew , Mudie, Laura , Stebbings, Lucy , Largaespada, David A. , Wessels, L. F. A. , Richard, Stephane , Kahnoski, Richard J. , Anema, John , A.Tuveson, David , Perez-Mancera, Pedro A. , Mustonen, Ville , Fischer, Andrej , Adams, David J. , Rust, Alistair , Chan-on, Waraporn , Subimerb, Chutima , Dykema, Karl , Furge, Kyle , Campbell, Peter J. , Teh, Bin Tean , Stratton, Michael R. and Futreal, P. Andrew
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Renal-carcinoma-inducing oncogene
Using large-scale exome sequencing, Andrew Futreal and colleagues have identified a second frequently mutated gene (after
VHL
) in clear cell renal cell carcinomas, the most frequent type of kidney cancer.
PBRM1
, a member of the SWI/SNF complex involved in transcriptional regulation, is mutated in a...
Alternative Titles
Full title
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
Authors, Artists and Contributors
Author / Creator
Tarpey, Patrick
Raine, Keiran
Huang, Dachuan
Ong, Choon Kiat
Stephens, Philip
Davies, Helen
Jones, David
Lin, Meng-Lay
Teague, Jon
Bignell, Graham
Butler, Adam
Cho, Juok
Dalgliesh, Gillian L.
Galappaththige, Danushka
Greenman, Chris
Hardy, Claire
Jia, Mingming
Latimer, Calli
Lau, King Wai
Marshall, John
McLaren, Stuart
Menzies, Andrew
Mudie, Laura
Stebbings, Lucy
Largaespada, David A.
Wessels, L. F. A.
Richard, Stephane
Kahnoski, Richard J.
Anema, John
A.Tuveson, David
Perez-Mancera, Pedro A.
Mustonen, Ville
Fischer, Andrej
Adams, David J.
Rust, Alistair
Chan-on, Waraporn
Subimerb, Chutima
Dykema, Karl
Furge, Kyle
Campbell, Peter J.
Teh, Bin Tean
Stratton, Michael R.
Futreal, P. Andrew
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3030920
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3030920
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature09639
