A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular...
A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Contents
Vascular endothelial growth factor (VEGF) has two highly homologous tyrosine kinase receptors: Flt‐1 (VEGFR‐1) and KDR (VEGFR‐2). KDR is strongly phosphorylated on tyrosines and can transmit mitogenic and motogenic signals following VEGF binding, while Flt‐1 is markedly less effective in mediating such functions. To dissect the regions that account...
Alternative Titles
Full title
A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_306589
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_306589
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1093/emboj/19.15.4064
