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Determinism and stochasticity during maturation of the zebrafish antibody repertoire

Determinism and stochasticity during maturation of the zebrafish antibody repertoire

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3069157

Determinism and stochasticity during maturation of the zebrafish antibody repertoire

About this item

Full title

Determinism and stochasticity during maturation of the zebrafish antibody repertoire

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (13), p.5348-5353

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

It is thought that the adaptive immune system of immature organisms follows a more deterministic program of antibody creation than is found in adults. We used high-throughput sequencing to characterize the diversifying antibody repertoire in zebrafish over five developmental time points. We found that the immune system begins in a highly stereotype...

Alternative Titles

Full title

Determinism and stochasticity during maturation of the zebrafish antibody repertoire

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3069157

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3069157

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1014277108

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