Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
About this item
Full title
Author / Creator
Kharas, Michael G , Lengner, Christopher J , Al-Shahrour, Fatima , Bullinger, Lars , Ball, Brian , Zaidi, Samir , Morgan, Kelly , Tam, Winnie , Paktinat, Mahnaz , Okabe, Rachel , Gozo, Maricel , Einhorn, William , Lane, Steven W , Scholl, Claudia , Fröhling, Stefan , Fleming, Mark , Ebert, Benjamin L , Gilliland, D Gary , Jaenisch, Rudolf and Daley, George Q
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The authors uncover a new role for the RNA-binding protein Msi2 in the regulation of hematopoietic stem cell homeostasis and leukemogenesis. Msi2 is required for the maintenance of the balance between progenitor renewal and differentiation, and its overexpression cooperates with oncogenic events to induce aggressive leukemia. Msi2 expression is als...
Alternative Titles
Full title
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
Authors, Artists and Contributors
Author / Creator
Lengner, Christopher J
Al-Shahrour, Fatima
Bullinger, Lars
Ball, Brian
Zaidi, Samir
Morgan, Kelly
Tam, Winnie
Paktinat, Mahnaz
Okabe, Rachel
Gozo, Maricel
Einhorn, William
Lane, Steven W
Scholl, Claudia
Fröhling, Stefan
Fleming, Mark
Ebert, Benjamin L
Gilliland, D Gary
Jaenisch, Rudolf
Daley, George Q
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3090658
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3090658
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2187
