Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the...
Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor
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Publisher
Basel: Basel : SP Birkhäuser Verlag Basel
Journal title
Language
English
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Publication information
Publisher
Basel: Basel : SP Birkhäuser Verlag Basel
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Scope and Contents
Contents
The thyrotropin receptor (TSHR) exhibits elevated cAMP signaling in the basal state and becomes fully activated by thyrotropin. Previously we presented evidence that small-molecule ligands act allosterically within the transmembrane region in contrast to the orthosteric extracellular hormone-binding sites. Our goal in this study was to identify pos...
Alternative Titles
Full title
Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3099415
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3099415
Other Identifiers
ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-010-0451-2
