Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on...
Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
LINE-1s (L1, Long Interspersed Element-1) are the most abundant autonomous non-LTR retrotransposons in the human genome and replicate by reverse transcription of an RNA intermediate. Full-length L1 encodes two open reading frames (ORF1, ORF2) and ORF2 has reverse transcriptase activity.
Here we expressed human L1 RT in E. coli and the purified p...
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Full title
Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3103432
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3103432
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ISSN
1471-2091
E-ISSN
1471-2091
DOI
10.1186/1471-2091-12-18
