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Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice

Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3104738

Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice

About this item

Full title

Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2011-06, Vol.121 (6), p.2264-2277

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are 2 similar diseases characterized by a cytokine storm, overwhelming inflammation, multiorgan dysfunction, and death. Animal models of HLH suggest that disease is driven by IFN-γ produced by CD8⁺ lymphocytes stimulated by persistent antigen exposure. In these models...

Alternative Titles

Full title

Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3104738

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3104738

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI43157

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