Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice
Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice
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United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are 2 similar diseases characterized by a cytokine storm, overwhelming inflammation, multiorgan dysfunction, and death. Animal models of HLH suggest that disease is driven by IFN-γ produced by CD8⁺ lymphocytes stimulated by persistent antigen exposure. In these models...
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Full title
Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3104738
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3104738
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI43157
