Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance
Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Interleukin 10 (IL-10) and regulatory T cells (Tregs) maintain tolerance to intestinal microorganisms. However,
Il10
−/−
Rag2
−/−
mice, which lack IL-10 and Tregs, remain healthy, suggesting the existence of other mechanisms of tolerance. Here, we identify suppressor of cytokine signalling 1 (SOCS1) as an essential mediator of immune...
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Full title
Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3105338
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3105338
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms1181
