Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver...
Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice
About this item
Full title
Author / Creator
Kodama, Takahiro , Takehara, Tetsuo , Hikita, Hayato , Shimizu, Satoshi , Shigekawa, Minoru , Tsunematsu, Hinako , Li, Wei , Miyagi, Takuya , Hosui, Atsushi , Tatsumi, Tomohide , Ishida, Hisashi , Kanto, Tatsuya , Hiramatsu, Naoki , Kubota, Satoshi , Takigawa, Masaharu , Tomimaru, Yoshito , Tomokuni, Akira , Nagano, Hiroaki , Doki, Yuichiro , Mori, Masaki and Hayashi, Norio
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
The tumor suppressor p53 has been implicated in the pathogenesis of non-cancer-related conditions such as insulin resistance, cardiac failure, and early aging. In addition, accumulation of p53 has been observed in the hepatocytes of individuals with fibrotic liver diseases, but the significance of this is not known. Herein, we have mechanistically...
Alternative Titles
Full title
Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice
Authors, Artists and Contributors
Author / Creator
Takehara, Tetsuo
Hikita, Hayato
Shimizu, Satoshi
Shigekawa, Minoru
Tsunematsu, Hinako
Li, Wei
Miyagi, Takuya
Hosui, Atsushi
Tatsumi, Tomohide
Ishida, Hisashi
Kanto, Tatsuya
Hiramatsu, Naoki
Kubota, Satoshi
Takigawa, Masaharu
Tomimaru, Yoshito
Tomokuni, Akira
Nagano, Hiroaki
Doki, Yuichiro
Mori, Masaki
Hayashi, Norio
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3148730
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3148730
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI44957
