Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse...
Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Huntington disease (HD) is a devastating neurodegenerative disorder for which there are no disease-modifying treatments. Previous studies have proposed that activation of the heat shock response (HSR) via the transcription factor heat shock factor 1 (HSF1) may be of therapeutic benefit. However, the effect of disease progression on the HSR and the...
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Full title
Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3148745
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3148745
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI57413
