Proteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension
Proteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension
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Publisher
Washington, DC: American Association for the Advancement of Science
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Language
English
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Washington, DC: American Association for the Advancement of Science
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Contents
Heparan and chondroitin sulfate proteoglycans (HSPGs and CSPGs, respectively) regulate numerous cell surface signaling events, with typically opposite effects on cell function. CSPGs inhibit nerve regeneration through receptor protein tyrosine phosphatase sigma (RPTPσ). Here we report that RPTPσ acts bimodally in sensory neuron extension, mediating...
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Full title
Proteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3154093
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3154093
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ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.1200840
