Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Srinivasan Yegnasubramanian and colleagues show that androgen signaling promotes recruitment of androgen receptor and TOP2B to sites of
TMPRSS2
-
ERG
genomic breakpoints, triggering TOP2B-mediated double-strand breaks. These findings provide insights into the mechanism underlying this common prostate cancer gene fusion event.
DNA dou...
Alternative Titles
Full title
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3157086
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3157086
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.613
