Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA...
Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The biological role of 2′-
O
-methylation of host and viral mRNA has remained elusive. Thiel and co-workers show that this modification modulates the induction of type I interferon and sensitivity to interferon.
The 5′ cap structures of higher eukaryote mRNAs have ribose 2′-
O
-methylation. Likewise, many viruses that replicate in th...
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Full title
Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3182538
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3182538
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ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/ni.1979
