Ligand discovery from a dopamine D3 receptor homology model and crystal structure
Ligand discovery from a dopamine D3 receptor homology model and crystal structure
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
A virtual screen of the GPCR D3R based on a homology model prior to publication of the crystal structure and a subsequent virtual screen based on the crystal structure of the receptor once it became available both identified new ligands with verified activities.
G protein–coupled receptors (GPCRs) are intensely studied as drug targets and for th...
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Full title
Ligand discovery from a dopamine D3 receptor homology model and crystal structure
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3197762
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3197762
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.662
